TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells

TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells

Neuroinflammation related to microglial activation plays an important role in neurodegenerative diseases. Translocator protein 18 kDa (TSPO), a biomarker of reactive gliosis, its ligands can reduce neuroinflammation and can be used to treat neurodegenerative diseases. Therefore, we explored whether...

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Bibliographic Details
Main Authors: Hao Feng, Yongxin Liu, Rui Zhang, Yingxia Liang, Lina Sun, Nannan Lan, Baoyu Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
TSPO
NLRP3 inflammasome
PK11195
midazolam
neurodegenerative diseases
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.544431/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.544431/full

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