HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.
Bibliographic Details
| Main Authors: |
Ping-Chieh Pao,
Debasis Patnaik,
L. Ashley Watson,
Fan Gao,
Ling Pan,
Jun Wang,
Chinnakkaruppan Adaikkan,
Jay Penney,
Hugh P. Cam,
Wen-Chin Huang,
Lorena Pantano,
Audrey Lee,
Alexi Nott,
Trongha X. Phan,
Elizabeta Gjoneska,
Sara Elmsaouri,
Stephen J. Haggarty,
Li-Huei Tsai |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-16361-y
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