Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection

Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection

For many of the most important human bacterial infections, invasive disease severity is fueled by the cell damaging and pro-inflammatory effects of secreted pore-forming toxins (PFTs). Isogenic PFT-knockout mutants, e.g., <i>Staphylococcus aureus</i> lacking &#945;-toxin or <i>...

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Bibliographic Details
Main Authors: Tamara Escajadillo, Victor Nizet
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Toxins
Subjects:
Pore-forming toxin
bacterial infection
virulence factor
pharmacology
adjunctive therapy
Online Access:https://www.mdpi.com/2072-6651/10/12/542

Internet

https://www.mdpi.com/2072-6651/10/12/542

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