Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) alleles[S]

Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) alleles[S]

Plasma lipoprotein (a) [Lp(a)] levels are largely determined by variation in the LPA gene, which codes for apo(a). Genome-wide association studies (GWASs) have identified nonsynonymous variants in LPA that associate with low Lp(a) levels, although their effect on apo(a) function is unknown. We inves...

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Bibliographic Details
Main Authors: Benjamin M. Morgan, Aimee N. Brown, Nikita Deo, Tom W.R. Harrop, George Taiaroa, Peter D. Mace, Sigurd M. Wilbanks, Tony R. Merriman, Michael J.A. Williams, Sally P.A. McCormick
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein (a)
endoplasmic reticulum
Golgi
kringle structure
null allele
protein modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520435266

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