Spatial competition constrains resistance to targeted cancer therapy

Spatial competition constrains resistance to targeted cancer therapy

Adaptive therapy aims to control tumours by exploiting competition between therapy-sensitive and resistant cells. Here, the authors show that tumour spatial structure is a critical parameter for adaptive therapy as competition for space increases fitness differentials, allowing suppression of resist...

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Main Authors: Katarina Bacevic, Robert Noble, Ahmed Soffar, Orchid Wael Ammar, Benjamin Boszonyik, Susana Prieto, Charles Vincent, Michael E. Hochberg, Liliana Krasinska, Daniel Fisher
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01516-1
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spelling doaj-319e6d8db9064cf9bdccfcfa5db863302021-05-11T07:06:34ZengNature Publishing GroupNature Communications2041-17232017-12-018111510.1038/s41467-017-01516-1Spatial competition constrains resistance to targeted cancer therapyKatarina Bacevic0Robert Noble1Ahmed Soffar2Orchid Wael Ammar3Benjamin Boszonyik4Susana Prieto5Charles Vincent6Michael E. Hochberg7Liliana Krasinska8Daniel Fisher9IGMM, CNRS, University of MontpellierISEM, University of MontpellierIGMM, CNRS, University of MontpellierIGMM, CNRS, University of MontpellierIGMM, CNRS, University of MontpellierIGMM, CNRS, University of MontpellierIRCM, InsermISEM, University of MontpellierIGMM, CNRS, University of MontpellierIGMM, CNRS, University of MontpellierAdaptive therapy aims to control tumours by exploiting competition between therapy-sensitive and resistant cells. Here, the authors show that tumour spatial structure is a critical parameter for adaptive therapy as competition for space increases fitness differentials, allowing suppression of resistance with low-dose treatments.https://doi.org/10.1038/s41467-017-01516-1
collection DOAJ
language English
format Article
sources DOAJ
author Katarina Bacevic
Robert Noble
Ahmed Soffar
Orchid Wael Ammar
Benjamin Boszonyik
Susana Prieto
Charles Vincent
Michael E. Hochberg
Liliana Krasinska
Daniel Fisher
spellingShingle Katarina Bacevic
Robert Noble
Ahmed Soffar
Orchid Wael Ammar
Benjamin Boszonyik
Susana Prieto
Charles Vincent
Michael E. Hochberg
Liliana Krasinska
Daniel Fisher
Spatial competition constrains resistance to targeted cancer therapy
Nature Communications
author_facet Katarina Bacevic
Robert Noble
Ahmed Soffar
Orchid Wael Ammar
Benjamin Boszonyik
Susana Prieto
Charles Vincent
Michael E. Hochberg
Liliana Krasinska
Daniel Fisher
author_sort Katarina Bacevic
title Spatial competition constrains resistance to targeted cancer therapy
title_short Spatial competition constrains resistance to targeted cancer therapy
title_full Spatial competition constrains resistance to targeted cancer therapy
title_fullStr Spatial competition constrains resistance to targeted cancer therapy
title_full_unstemmed Spatial competition constrains resistance to targeted cancer therapy
title_sort spatial competition constrains resistance to targeted cancer therapy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description Adaptive therapy aims to control tumours by exploiting competition between therapy-sensitive and resistant cells. Here, the authors show that tumour spatial structure is a critical parameter for adaptive therapy as competition for space increases fitness differentials, allowing suppression of resistance with low-dose treatments.
url https://doi.org/10.1038/s41467-017-01516-1
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