A Wittig-olefination–Claisen-rearrangement approach to the 3-methylquinoline-4-carbaldehyde synthesis

A Wittig-olefination–Claisen-rearrangement approach to the 3-methylquinoline-4-carbaldehyde synthesis

Efficient syntheses are described for the synthetically important 3-methylquinoline-4-carbaldehydes 6a–h from o-nitrobenzaldehydes 1a–h employing a Wittig-olefination–Claisen-rearrangement protocol. The Wittig reaction of o-nitrobenzaldehydes with crotyloxymethylene triphenylphosphorane afforded cro...

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Bibliographic Details
Main Authors: Mukund G. Kulkarni, Mayur P. Desai, Deekshaputra R. Birhade, Yunus B. Shaikh, Ajit N. Dhatrak, Ramesh Gannimani
Format: Article
Language:English
Published: Beilstein-Institut 2012-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
acetal
Claisen rearrangement
oxidative cleavage
ring-closure
Wittig olefination
Online Access:https://doi.org/10.3762/bjoc.8.197

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