High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure

High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure

Clevidipine, a dihydropyridine (DHP) analogue, lowers blood pressure (BP) by inhibiting l-type calcium channels (CaV1.2; gene CACNA1C) predominantly located in vascular smooth muscle (VSM). However, clinical observations suggest that clevidipine acts by a more complex mechanism. Clevidipine more pot...

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Bibliographic Details
Main Authors: Gerhard P. Dahl, Gregory E. Conner, Feng Qiu, Junjie Wang, Edward Spindler, Jason A. Campagna, H. Peter Larsson
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:EBioMedicine
Subjects:
Clevidipine
Voltage-gated calcium channels
CaV1.2
Pannexin
Dyspnea
Hypertensive heart failure
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302845

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