The STIM1-binding site nexus remotely controls Orai1 channel gating

How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore.

Bibliographic Details
Main Authors:	Yandong Zhou, Xiangyu Cai, Natalia A. Loktionova, Xianming Wang, Robert M. Nwokonko, Xizhuo Wang, Youjun Wang, Brad S. Rothberg, Mohamed Trebak, Donald L. Gill
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13725

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spelling	doaj-319437aa2a59462e85ad73d129f7e2ee2021-05-11T10:56:16ZengNature Publishing GroupNature Communications2041-17232016-12-017111310.1038/ncomms13725The STIM1-binding site nexus remotely controls Orai1 channel gatingYandong Zhou0Xiangyu Cai1Natalia A. Loktionova2Xianming Wang3Robert M. Nwokonko4Xizhuo Wang5Youjun Wang6Brad S. Rothberg7Mohamed Trebak8Donald L. Gill9Department of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineBeijing Key Laboratory of Gene Resources and Molecular Development College of Life Sciences, Beijing Normal UniversityDepartment of Biochemistry, Temple University School of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineHow plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore.https://doi.org/10.1038/ncomms13725
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yandong Zhou Xiangyu Cai Natalia A. Loktionova Xianming Wang Robert M. Nwokonko Xizhuo Wang Youjun Wang Brad S. Rothberg Mohamed Trebak Donald L. Gill
spellingShingle	Yandong Zhou Xiangyu Cai Natalia A. Loktionova Xianming Wang Robert M. Nwokonko Xizhuo Wang Youjun Wang Brad S. Rothberg Mohamed Trebak Donald L. Gill The STIM1-binding site nexus remotely controls Orai1 channel gating Nature Communications
author_facet	Yandong Zhou Xiangyu Cai Natalia A. Loktionova Xianming Wang Robert M. Nwokonko Xizhuo Wang Youjun Wang Brad S. Rothberg Mohamed Trebak Donald L. Gill
author_sort	Yandong Zhou
title	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_short	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_full	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_fullStr	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_full_unstemmed	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_sort	stim1-binding site nexus remotely controls orai1 channel gating
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-12-01
description	How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore.
url	https://doi.org/10.1038/ncomms13725
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The STIM1-binding site nexus remotely controls Orai1 channel gating

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