Pyran Rings Containing Polyketides from Penicillium raistrickii

• Main Authors: Li-Ying Ma, De-Sheng Liu, De-Guo Li, Yu-Ling Huang, Hui-Hui Kang, Chun-Hua Wang, Wei-Zhong Liu
• Format: Article
• Language: English
• Published: MDPI AG 2016-12-01
• Series: Marine Drugs
• Subjects: Penicillium raistrickii; α-pyrone; isocoumarin; polyketides; saline soil-derived fungus
• Online Access: http://www.mdpi.com/1660-3397/15/1/2
• ISSN: 1660-3397

Five new pyran rings containing polyketides, penicipyrans A–E (1–5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher’s method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC50 values of 4.4 and 8.5 μM, respectively.