Concordance between TP53 alterations in blood and tissue: impact of time interval, biopsy site, cancer type and circulating tumor DNA burden

Concordance between TP53 alterations in blood and tissue: impact of time interval, biopsy site, cancer type and circulating tumor DNA burden

We examined the impact of spatial, temporal, histologic, and quantitative factors on concordance between TP53 alterations in tissue DNA vs in circulating tumor DNA (ctDNA). Four hundred and thirty‐three patients underwent next‐generation sequencing (NGS) in which both tissue and blood samples were e...

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Bibliographic Details
Main Authors: Cheyennedra C. Bieg‐Bourne, Ryosuke Okamura, Razelle Kurzrock
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Molecular Oncology
Subjects:
cancer
concordance
ctDNA
genomics
TP53
Online Access:https://doi.org/10.1002/1878-0261.12672

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