An analytical review on probable anti-parkinsonian effect of modafinil

An analytical review on probable anti-parkinsonian effect of modafinil

Restoring dopamine levels in Parkinson's disese (PD) has been considered as the main symptomatic therapy. In this strategy, long-term administration of L-DOPA results in motor impairments. This necessitates novel approaches in that PD is tackled with lower deleterious side effects. . Modafinil...

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Main Authors: Mehdi Farhoudi, Saeed Sadigh-Eteghad, Sasan Andalib, Manouchehr Vafaee, Mojtaba Ziaee, Javad Mahmoudi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2013-12-01
Series:Journal of Analytical Research in Clinical Medicine
Subjects:
Parkinson's disease
Modafinil
Doapmine
Oxidative stress
Online Access:http://journals.tbzmed.ac.ir/JARCM/Manuscript/JARCM-1-58.pdf
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spelling doaj-31809dd8a65c403a8099e19447c983882020-11-24T20:48:59ZengTabriz University of Medical SciencesJournal of Analytical Research in Clinical Medicine2345-49702013-12-0112586210.5681/jarcm.2013.008JARCM_795_20130427141553An analytical review on probable anti-parkinsonian effect of modafinilMehdi Farhoudi0Saeed Sadigh-Eteghad1Sasan Andalib2Manouchehr Vafaee3Mojtaba Ziaee4Javad Mahmoudi5Professor, Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, IranInstructor, Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, IranInstructor, Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, IranAssociate Professor, Department of Neuroscience and Pharmacology, School of Health Sciences, University of Copenhagen,Copenhagen, DenmarkInstructor, Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, IranInstructor, Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, IranRestoring dopamine levels in Parkinson's disese (PD) has been considered as the main symptomatic therapy. In this strategy, long-term administration of L-DOPA results in motor impairments. This necessitates novel approaches in that PD is tackled with lower deleterious side effects. . Modafinil is a wake promoting agent clinically used for treatment of excessive day time sleeping. This medication increases dopamine levels and decreases oxidative stress and can thus exert anti-parkinsonian effect. Therefore, this review will give an account of the probable anti-parkinsonian mechanisms of modafinil.http://journals.tbzmed.ac.ir/JARCM/Manuscript/JARCM-1-58.pdfParkinson's diseaseModafinilDoapmineOxidative stress
collection DOAJ
language English
format Article
sources DOAJ
author Mehdi Farhoudi
Saeed Sadigh-Eteghad
Sasan Andalib
Manouchehr Vafaee
Mojtaba Ziaee
Javad Mahmoudi
spellingShingle Mehdi Farhoudi
Saeed Sadigh-Eteghad
Sasan Andalib
Manouchehr Vafaee
Mojtaba Ziaee
Javad Mahmoudi
An analytical review on probable anti-parkinsonian effect of modafinil
Journal of Analytical Research in Clinical Medicine
Parkinson's disease
Modafinil
Doapmine
Oxidative stress
author_facet Mehdi Farhoudi
Saeed Sadigh-Eteghad
Sasan Andalib
Manouchehr Vafaee
Mojtaba Ziaee
Javad Mahmoudi
author_sort Mehdi Farhoudi
title An analytical review on probable anti-parkinsonian effect of modafinil
title_short An analytical review on probable anti-parkinsonian effect of modafinil
title_full An analytical review on probable anti-parkinsonian effect of modafinil
title_fullStr An analytical review on probable anti-parkinsonian effect of modafinil
title_full_unstemmed An analytical review on probable anti-parkinsonian effect of modafinil
title_sort analytical review on probable anti-parkinsonian effect of modafinil
publisher Tabriz University of Medical Sciences
series Journal of Analytical Research in Clinical Medicine
issn 2345-4970
publishDate 2013-12-01
description Restoring dopamine levels in Parkinson's disese (PD) has been considered as the main symptomatic therapy. In this strategy, long-term administration of L-DOPA results in motor impairments. This necessitates novel approaches in that PD is tackled with lower deleterious side effects. . Modafinil is a wake promoting agent clinically used for treatment of excessive day time sleeping. This medication increases dopamine levels and decreases oxidative stress and can thus exert anti-parkinsonian effect. Therefore, this review will give an account of the probable anti-parkinsonian mechanisms of modafinil.
topic Parkinson's disease
Modafinil
Doapmine
Oxidative stress
url http://journals.tbzmed.ac.ir/JARCM/Manuscript/JARCM-1-58.pdf
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