An analytical review on probable anti-parkinsonian effect of modafinil

An analytical review on probable anti-parkinsonian effect of modafinil

Restoring dopamine levels in Parkinson's disese (PD) has been considered as the main symptomatic therapy. In this strategy, long-term administration of L-DOPA results in motor impairments. This necessitates novel approaches in that PD is tackled with lower deleterious side effects. . Modafinil...

Full description

Bibliographic Details
Main Authors: Mehdi Farhoudi, Saeed Sadigh-Eteghad, Sasan Andalib, Manouchehr Vafaee, Mojtaba Ziaee, Javad Mahmoudi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2013-12-01
Series:Journal of Analytical Research in Clinical Medicine
Subjects:
Parkinson's disease
Modafinil
Doapmine
Oxidative stress
Online Access:http://journals.tbzmed.ac.ir/JARCM/Manuscript/JARCM-1-58.pdf
Description
Summary:Restoring dopamine levels in Parkinson's disese (PD) has been considered as the main symptomatic therapy. In this strategy, long-term administration of L-DOPA results in motor impairments. This necessitates novel approaches in that PD is tackled with lower deleterious side effects. . Modafinil is a wake promoting agent clinically used for treatment of excessive day time sleeping. This medication increases dopamine levels and decreases oxidative stress and can thus exert anti-parkinsonian effect. Therefore, this review will give an account of the probable anti-parkinsonian mechanisms of modafinil.
ISSN:2345-4970

Similar Items