Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner

Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner

Atomoxetine, a neuroactive drug, is approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). It is primarily known as a high affinity blocker of the noradrenaline transporter, whereby its application leads to an increased level of the corresponding neurotransmitter in different...

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Bibliographic Details
Main Authors: Karl Josef Föhr, Ariadni Nastos, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, David Alexander Christian Messerer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
atomoxetine
hNav1.5
cardiotoxicity
antiarrhythmic
patch clamp
attention-deficit/hyperactivity disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.622489/full

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