Silencing of a large microRNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor

Silencing of a large microRNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor

<p>Abstract</p> <p>Background</p> <p>Metastatic melanoma is a devastating disease with limited therapeutic options. MicroRNAs (miRNAs) are small non coding RNA molecules with important roles in post-transcriptional gene expression regulation, whose aberrant expression h...

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Bibliographic Details
Main Authors: Zehavi Liron, Avraham Roi, Barzilai Aviv, Bar-Ilan Dalia, Navon Roy, Sidi Yechezkel, Avni Dror, Leibowitz-Amit Raya
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Molecular Cancer
Subjects:
microRNA
Melanoma
IGF1R
mir-376a
mir-376c, Epigenetics
Online Access:http://www.molecular-cancer.com/content/11/1/44

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