Orthogonal programming of heterogeneous micro-mechano-environments and geometries in three-dimensional bio-stereolithography

Tuning the mechanical properties of extracellular matrix is of great interest in tissue engineering but spatial control over stiffness in hydrogels has been demonstrated in two dimensions only. Here the authors developed a layer-by-layer printing technique which uses oxygen inhibition to control the...

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Bibliographic Details
Main Authors: Hang Yin, Yonghui Ding, Yao Zhai, Wei Tan, Xiaobo Yin
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06685-1
Description
Summary:Tuning the mechanical properties of extracellular matrix is of great interest in tissue engineering but spatial control over stiffness in hydrogels has been demonstrated in two dimensions only. Here the authors developed a layer-by-layer printing technique which uses oxygen inhibition to control the heterogeneous stiffness in 3D printed structures.
ISSN:2041-1723