Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs

Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs

Abstract Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role in MDR, but the mechanism behind this link remains unclear. We found that the expression of multiple ABC transporters was elevated...

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Bibliographic Details
Main Authors: Maegan Miang Kee Lim, Jonathan Wei Kiat Wee, Jen Chi Soong, Damien Chua, Wei Ren Tan, Marco Lizwan, Yinliang Li, Ziqiang Teo, Wilson Wen Bin Goh, Pengcheng Zhu, Nguan Soon Tan
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Cancer
Subjects:
Epithelial-mesenchymal transition
Multi-drug resistance
Angiopoietin-like 4
ATP-binding cassette transporters
Online Access:http://link.springer.com/article/10.1186/s12943-018-0904-z

Internet

http://link.springer.com/article/10.1186/s12943-018-0904-z

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