Cell Derived Matrix Fibulin-1 Associates With Epidermal Growth Factor Receptor to Inhibit Its Activation, Localization and Function in Lung Cancer Calu-1 Cells

Cell Derived Matrix Fibulin-1 Associates With Epidermal Growth Factor Receptor to Inhibit Its Activation, Localization and Function in Lung Cancer Calu-1 Cells

Epidermal Growth Factor Receptor (EGFR) is a known promoter of tumor progression and is overexpressed in lung cancers. Growth factor receptors (including EGFR) are known to interact with extracellular matrix (ECM) proteins, which regulate their activation and function. Fibulin-1 (FBLN1) is a major c...

Full description

Bibliographic Details
Main Authors: Keerthi Harikrishnan, Omkar Joshi, Saili Madangirikar, Nagaraj Balasubramanian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
FBLN1
EGFR
ECM
cell derived matrix
matrix microenvironment
lung cancer
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00522/full

Similar Items

Similar Items