Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.

Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.

Persistence of hepatitis B virus (HBV) infection requires covalently closed circular (ccc)DNA formation and amplification, which can occur via intracellular recycling of the viral polymerase-linked relaxed circular (rc) DNA genomes present in virions. Here we reveal a fundamental difference between...

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Bibliographic Details
Main Authors:	Josef Köck, Christine Rösler, Jing-Jing Zhang, Hubert E Blum, Michael Nassal, Christian Thoma
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-01-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC2932716?pdf=render

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