Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression

Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression

Osteosarcoma (OS) is a serious primary bone malignant tumor that can easily affect children and adolescents. Chemotherapy is one of the important and feasible clinical treatment strategies for the treatment of OS at present, which is severely limited due to insufficient retention time, poor penetrat...

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Bibliographic Details
Main Authors: Hongli Shan, Ke Li, Duoyi Zhao, Changliang Chi, Qinyuan Tan, Xiaoqing Wang, Jinhai Yu, Meihua Piao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
thermo-sensitive hydrogel
local injection
controlled drug release
osteosarcoma
synergistic chemotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00573/full

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