Identification of tyrosine-9 of MAVS as critical target for inducible phosphorylation that determines activation.

Identification of tyrosine-9 of MAVS as critical target for inducible phosphorylation that determines activation.

BACKGROUND: Innate immunity to viruses involves receptors such as RIG-I, which senses viral RNA and triggers an IFN-β signaling pathway involving the outer mitochondrial membrane protein MAVS. However, the functional status of MAVS phosphorylation remains elusive. METHODOLOGY/PRINCIPAL FINDINGS: Her...

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Main Authors: Chaoyang Wen, Zhifeng Yan, Xiaoli Yang, Kai Guan, Changzhi Xu, Ting Song, Zirui Zheng, Wenjun Wang, Ying Wang, Man Zhao, Yanhong Zhang, Tao Xu, Jianping Dou, Jingmei Liu, Quanbin Xu, Xiang He, Congwen Wei, Hui Zhong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3406013?pdf=render

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