COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE

• Main Authors: Olga Samodai, Konstantin Reznikov
• Format: Article
• Language: English
• Published: Pensoft Publishers 2017-09-01
• Series: Research Results in Pharmacology
• Subjects: acne; adolescence; adult; acne complex therapy; ps
• Online Access: https://rrpharmacology.pensoft.net/article/31099/download/pdf/

Introduction: The problem of complex therapy of acne attracts the attention of researchers because it accompanied with significant cosmetic defect and caused serious patient’s experiences. Objectives: The aim of this study was to find ways to increase the efficacy and safety of treating patients with acne by complex pharmacological correction of its manifestations. Methods: The study included 110 people (32 men and 78 women) aged from 17 to 35 years, divided into 5 equal groups (according to the type of therapy) and observed for 6 months. All the patients underwent a comprehensive examination, including calculation of the dermatological index of acne (DIA), psychometric tests as well as an immunological study. Results and discussion: Monotherapy with combined topical agents leads to a decrease in DIA (48.75%) and the length of remission for more than 6 months in 46.4% of observations. Phabomotisol decreased DIA count and improved psychometric parameters. Ionized liquid (IL) led to an increase in CD4 + lymphocytes (14.48%) and immunoregulatory index (40.88%), decreased in the number of CD8 + lymphocytes (17.92%). The most effective combination was phabomotisol and IL (negative redox potential): DIA decreased (74.36%), remission of more than 1 year was observed in 22.7% patients. Conclusion: Effectiveness therapy with phabomotizol was shown. Effectiveness of IL in the complex treatment of acne in the medium-severe course of the disease is estimated for the first time. Presence of immunotropic properties of IL was established. Possibility of achieving long-term remission without the use of antibiotic therapy was demonstrated.