Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia

Introduction: The search for and development of new highly active medications and their combinations of the appropriate direction of action remains an urgent problem due to the complications of diabetes mellitus, especially burdened with atherosclerosis, including skin and...

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Main Authors: Olga N. Gulevskaya, Pavel A. Galenko-Yaroshevsky, Svetlana A. Lebedeva, Galina V. Sukoyan, Ivan I. Pavlyuchenko, Anait V. Zelenskaya, Alexandr V. Uvarov, Kristina V. Tseluiko, Viktor L. Popkov, Andrey V. Zadorozhniy, Elena N. Chuyan, Marina Yu. Ravaeva, Pavel A. Galenko-Yaroshevsky Jr
Format: Article
Language:English
Published: Pensoft Publishers 2021-05-01
Series:Research Results in Pharmacology
Online Access:https://rrpharmacology.pensoft.net/article/54319/download/pdf/
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spelling doaj-3139a5267430448699c0a877fb5171dd2021-09-28T14:35:54ZengPensoft PublishersResearch Results in Pharmacology2658-381X2021-05-017211410.3897/rrpharmacology.7.5431954319Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemiaOlga N. Gulevskaya0Pavel A. Galenko-Yaroshevsky1Svetlana A. Lebedeva2Galina V. Sukoyan3Ivan I. Pavlyuchenko4Anait V. Zelenskaya5Alexandr V. Uvarov6Kristina V. Tseluiko7Viktor L. Popkov8Andrey V. Zadorozhniy9Elena N. Chuyan10Marina Yu. Ravaeva11Pavel A. Galenko-Yaroshevsky Jr12Kuban State Medical UniversityKuban State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityInternational Research Centre of Introduction of New Biomedical TechnologyKuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityRostov State Medical UniversityKuban State Medical UniversityRostov State Medical UniversityV.I. Vernadsky Crimean Federal UniversityV.I. Vernadsky Crimean Federal UniversityState Budgetary Healthcare Institution “City outpatients clinic No.17” of the Ministry of Health of Krasnodar Territory Introduction: The search for and development of new highly active medications and their combinations of the appropriate direction of action remains an urgent problem due to the complications of diabetes mellitus, especially burdened with atherosclerosis, including skin and vascular lesions. Materials and methods: The acute toxicity, histoprotective and dermatoprotective effects of mafusol, rexod, alprostadil and their combinations were studied in male rats with normoglycemia and alloxan diabetes complicated by exogenous hypercholesterolemia. Results: The combination of mafusol with rexod is less toxic than mafusol. In arteriovenous insufficiency of the tail, ischemia of the skin fold and skin flap, mafusol (6.25, 12.5 and 25.0 mg/kg in terms of fumarate), rexod (0.01 and 0.02 mg/kg) and especially their combination (6.25 and 0.01 mg/kg) have significant histoprotective, dermatoprotective, hypoglycemic and lipid-lowering effects, both in normoglycemia and alloxan diabetes complicated by exogenous hypercholesterolemia. Alprostadil (10 mg/kg) and especially its combination with mafusol (6.25 mg/kg) have a dermatoprotective effect. Discussion: Rexod reduces the acute toxicity of mafusol. The dermatoprotective effect of mafusol, rexod and, to a greater extent, their combination may be associated with increased microhemocirculation, antihypoxic properties and activation of energy processes in the skin, normalization of carbohydrate and lipid metabolism in alloxan diabetes, complicated by exogenous hypercholesterolemia, increased reserve capacity of the antioxidant system, and possibly with the ability of mafusol and rexod to reduce blood viscosity and improve rheological properties of the blood. The combination of mafusol with alprostadil increases the dermatoprotective activity of the latter. Conclusion: Combinations of mafusol with rexod and alprostadil can be recommended for clinical study as dermatoprotective agents for treating traumatic injuries and diabetes mellitus complicated by atherosclerosis. https://rrpharmacology.pensoft.net/article/54319/download/pdf/
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language English
format Article
sources DOAJ
author Olga N. Gulevskaya
Pavel A. Galenko-Yaroshevsky
Svetlana A. Lebedeva
Galina V. Sukoyan
Ivan I. Pavlyuchenko
Anait V. Zelenskaya
Alexandr V. Uvarov
Kristina V. Tseluiko
Viktor L. Popkov
Andrey V. Zadorozhniy
Elena N. Chuyan
Marina Yu. Ravaeva
Pavel A. Galenko-Yaroshevsky Jr
spellingShingle Olga N. Gulevskaya
Pavel A. Galenko-Yaroshevsky
Svetlana A. Lebedeva
Galina V. Sukoyan
Ivan I. Pavlyuchenko
Anait V. Zelenskaya
Alexandr V. Uvarov
Kristina V. Tseluiko
Viktor L. Popkov
Andrey V. Zadorozhniy
Elena N. Chuyan
Marina Yu. Ravaeva
Pavel A. Galenko-Yaroshevsky Jr
Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia
Research Results in Pharmacology
author_facet Olga N. Gulevskaya
Pavel A. Galenko-Yaroshevsky
Svetlana A. Lebedeva
Galina V. Sukoyan
Ivan I. Pavlyuchenko
Anait V. Zelenskaya
Alexandr V. Uvarov
Kristina V. Tseluiko
Viktor L. Popkov
Andrey V. Zadorozhniy
Elena N. Chuyan
Marina Yu. Ravaeva
Pavel A. Galenko-Yaroshevsky Jr
author_sort Olga N. Gulevskaya
title Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia
title_short Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia
title_full Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia
title_fullStr Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia
title_full_unstemmed Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia
title_sort mafusol and its combination with rexod as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia
publisher Pensoft Publishers
series Research Results in Pharmacology
issn 2658-381X
publishDate 2021-05-01
description Introduction: The search for and development of new highly active medications and their combinations of the appropriate direction of action remains an urgent problem due to the complications of diabetes mellitus, especially burdened with atherosclerosis, including skin and vascular lesions. Materials and methods: The acute toxicity, histoprotective and dermatoprotective effects of mafusol, rexod, alprostadil and their combinations were studied in male rats with normoglycemia and alloxan diabetes complicated by exogenous hypercholesterolemia. Results: The combination of mafusol with rexod is less toxic than mafusol. In arteriovenous insufficiency of the tail, ischemia of the skin fold and skin flap, mafusol (6.25, 12.5 and 25.0 mg/kg in terms of fumarate), rexod (0.01 and 0.02 mg/kg) and especially their combination (6.25 and 0.01 mg/kg) have significant histoprotective, dermatoprotective, hypoglycemic and lipid-lowering effects, both in normoglycemia and alloxan diabetes complicated by exogenous hypercholesterolemia. Alprostadil (10 mg/kg) and especially its combination with mafusol (6.25 mg/kg) have a dermatoprotective effect. Discussion: Rexod reduces the acute toxicity of mafusol. The dermatoprotective effect of mafusol, rexod and, to a greater extent, their combination may be associated with increased microhemocirculation, antihypoxic properties and activation of energy processes in the skin, normalization of carbohydrate and lipid metabolism in alloxan diabetes, complicated by exogenous hypercholesterolemia, increased reserve capacity of the antioxidant system, and possibly with the ability of mafusol and rexod to reduce blood viscosity and improve rheological properties of the blood. The combination of mafusol with alprostadil increases the dermatoprotective activity of the latter. Conclusion: Combinations of mafusol with rexod and alprostadil can be recommended for clinical study as dermatoprotective agents for treating traumatic injuries and diabetes mellitus complicated by atherosclerosis.
url https://rrpharmacology.pensoft.net/article/54319/download/pdf/
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