Thoracic aorta stent grafts design in terms of biomechanical investigations into flexibility
The present study aimed to design and optimize thoracic aorta stent grafts (SGs) based on the influence of geometric parameters on flexibility and durability. Five geometric parameters were selected, including strut height, strut number, strut radius, wire diameter, and graft thickness. Subsequently...
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doaj-31395b1136d54143af89d81833137c3b2021-04-07T01:28:37ZengAIMS PressMathematical Biosciences and Engineering1551-00182021-04-0118180081610.3934/mbe.2021042Thoracic aorta stent grafts design in terms of biomechanical investigations into flexibilityZongchao Liu0Linhui Wu1Junwei Yang2Fangsen Cui 3Pei Ho4Liping Wang5Jianghui Dong6Gongfa Chen 71. School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou 510006, China1. School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou 510006, China1. School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou 510006, China2. Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore 138632, Singapore3. Department of Cardiac, Thoracic & Vascular Surgery, National University Health System, Singapore 119228, Singapore4. UniSA Clinical & Health Sciences, University of South Australia, Adelaide SA 5001, Australia4. UniSA Clinical & Health Sciences, University of South Australia, Adelaide SA 5001, Australia1. School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou 510006, ChinaThe present study aimed to design and optimize thoracic aorta stent grafts (SGs) based on the influence of geometric parameters on flexibility and durability. Five geometric parameters were selected, including strut height, strut number, strut radius, wire diameter, and graft thickness. Subsequently, 16 finite element (FE) models were established with an orthogonal design consisting of five factors and four levels. The influences of a single factor and all the geometric parameters' influence magnitude on the device flexibility were then determined. The results showed that all the other parameters had an opposite effect on global and local flexibility except for the wire diameter. The graft thickness exhibited the most remarkable impact on the global flexibility of SGs, while the strut radius influenced flexibility slightly. However, for the local flexibility analysis, the graft thickness became the least significant factor, and the wire diameter exerted the most significant influence. The SG with better global flexibility can be guided easily in the tortuous vessels, and better local flexibility improves the sealing effect between the graft and aortic arch. In conclusion, this study's results indicated that these geometric parameters exerted different influences on flexibility and durability, providing a strategy for designing thoracic aorta SGs, especially for the thoracic aortic arch diseases.http://www.aimspress.com/article/doi/10.3934/mbe.2021042?viewType=HTMLfinite element methodflexibilitygeometric parametersorthogonal testthoracic aorta |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zongchao Liu Linhui Wu Junwei Yang Fangsen Cui Pei Ho Liping Wang Jianghui Dong Gongfa Chen |
spellingShingle |
Zongchao Liu Linhui Wu Junwei Yang Fangsen Cui Pei Ho Liping Wang Jianghui Dong Gongfa Chen Thoracic aorta stent grafts design in terms of biomechanical investigations into flexibility Mathematical Biosciences and Engineering finite element method flexibility geometric parameters orthogonal test thoracic aorta |
author_facet |
Zongchao Liu Linhui Wu Junwei Yang Fangsen Cui Pei Ho Liping Wang Jianghui Dong Gongfa Chen |
author_sort |
Zongchao Liu |
title |
Thoracic aorta stent grafts design in terms of biomechanical investigations into flexibility |
title_short |
Thoracic aorta stent grafts design in terms of biomechanical investigations into flexibility |
title_full |
Thoracic aorta stent grafts design in terms of biomechanical investigations into flexibility |
title_fullStr |
Thoracic aorta stent grafts design in terms of biomechanical investigations into flexibility |
title_full_unstemmed |
Thoracic aorta stent grafts design in terms of biomechanical investigations into flexibility |
title_sort |
thoracic aorta stent grafts design in terms of biomechanical investigations into flexibility |
publisher |
AIMS Press |
series |
Mathematical Biosciences and Engineering |
issn |
1551-0018 |
publishDate |
2021-04-01 |
description |
The present study aimed to design and optimize thoracic aorta stent grafts (SGs) based on the influence of geometric parameters on flexibility and durability. Five geometric parameters were selected, including strut height, strut number, strut radius, wire diameter, and graft thickness. Subsequently, 16 finite element (FE) models were established with an orthogonal design consisting of five factors and four levels. The influences of a single factor and all the geometric parameters' influence magnitude on the device flexibility were then determined. The results showed that all the other parameters had an opposite effect on global and local flexibility except for the wire diameter. The graft thickness exhibited the most remarkable impact on the global flexibility of SGs, while the strut radius influenced flexibility slightly. However, for the local flexibility analysis, the graft thickness became the least significant factor, and the wire diameter exerted the most significant influence. The SG with better global flexibility can be guided easily in the tortuous vessels, and better local flexibility improves the sealing effect between the graft and aortic arch. In conclusion, this study's results indicated that these geometric parameters exerted different influences on flexibility and durability, providing a strategy for designing thoracic aorta SGs, especially for the thoracic aortic arch diseases. |
topic |
finite element method flexibility geometric parameters orthogonal test thoracic aorta |
url |
http://www.aimspress.com/article/doi/10.3934/mbe.2021042?viewType=HTML |
work_keys_str_mv |
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