Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson’s Disease Model Induced by 6-OHDA

Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson’s Disease Model Induced by 6-OHDA

The disruption of neuronal iron homeostasis and oxidative stress are related to the pathogenesis of Parkinson’s disease (PD). Alpha-lipoic acid (ALA) is a naturally occurring enzyme cofactor with antioxidant and iron chelator properties and has many known effects. ALA has neuroprotective effects on...

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Bibliographic Details
Main Authors: Shengyan Tai, Qian Zheng, Suzhen Zhai, Ting Cai, Li Xu, Lizhu Yang, Ling Jiao, Chunlin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
alpha-lipoic acid
oxidative stress
chelation iron
Parkinson’s disease
iron homeostasis
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00612/full

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