Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis.

Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis.

Despite extensive research on the mechanisms of HLA-mediated immune control of HIV-1 pathogenesis, it is clear that much remains to be discovered, as exemplified by protective HLA alleles like HLA-B*81 which are associated with profound protection from CD4+ T cell decline without robust control of e...

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Main Authors: Daniel T Claiborne, Eileen P Scully, Christine D Palmer, Jessica L Prince, Gladys N Macharia, Jakub Kopycinski, Clive M Michelo, Howard W Wiener, Rachel Parker, Krystelle Nganou-Makamdop, Daniel Douek, Marcus Altfeld, Jill Gilmour, Matt A Price, Jianming Tang, William Kilembe, Susan A Allen, Eric Hunter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007981

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