Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma

Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma

Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s transition. Previous studies imply that changes in the cancer st...

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Main Authors: Yu-bao Lu MS, Tian-Jiao Sun MS, Yu-tong Chen MS, Zong-Yan Cai MS, Jia-Yu Zhao MS, Feng Miao MS, Yong-na Yang MS, Shi-Xin Wang MS
Format: Article
Language:English
Published: SAGE Publishing 2020-10-01
Series:Technology in Cancer Research & Treatment
Online Access:https://doi.org/10.1177/1533033820948053
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spelling doaj-3129b3b9af9943b0b25c97032c7d08452020-11-25T03:52:36ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-10-011910.1177/1533033820948053Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of GliomaYu-bao Lu MS0Tian-Jiao Sun MS1Yu-tong Chen MS2Zong-Yan Cai MS3Jia-Yu Zhao MS4Feng Miao MS5Yong-na Yang MS6Shi-Xin Wang MS7*Both authors contributed equally to this study and share first authorship.*Both authors contributed equally to this study and share first authorship. The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China Zhangye People's Hospital Affiliated to Hexi University, Zhangye, Gansu, China Department of Neurology, The First People’s Hospital of Lanzhou City, Lanzhou, Gansu, China School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, ChinaGlioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma.https://doi.org/10.1177/1533033820948053
collection DOAJ
language English
format Article
sources DOAJ
author Yu-bao Lu MS
Tian-Jiao Sun MS
Yu-tong Chen MS
Zong-Yan Cai MS
Jia-Yu Zhao MS
Feng Miao MS
Yong-na Yang MS
Shi-Xin Wang MS
spellingShingle Yu-bao Lu MS
Tian-Jiao Sun MS
Yu-tong Chen MS
Zong-Yan Cai MS
Jia-Yu Zhao MS
Feng Miao MS
Yong-na Yang MS
Shi-Xin Wang MS
Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
Technology in Cancer Research & Treatment
author_facet Yu-bao Lu MS
Tian-Jiao Sun MS
Yu-tong Chen MS
Zong-Yan Cai MS
Jia-Yu Zhao MS
Feng Miao MS
Yong-na Yang MS
Shi-Xin Wang MS
author_sort Yu-bao Lu MS
title Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_short Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_full Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_fullStr Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_full_unstemmed Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_sort targeting the epithelial-to-mesenchymal transition in cancer stem cells for a better clinical outcome of glioma
publisher SAGE Publishing
series Technology in Cancer Research & Treatment
issn 1533-0338
publishDate 2020-10-01
description Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma.
url https://doi.org/10.1177/1533033820948053
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