A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional activation of GAS6 and a set of SWI/SNF target genes.

Bibliographic Details
Main Authors:	Elena Grossi, Ivan Raimondi, Enrique Goñi, Jovanna González, Francesco P. Marchese, Vicente Chapaprieta, José I. Martín-Subero, Shuling Guo, Maite Huarte
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14623-3

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spelling	doaj-312881ea5ccf4917ac2bc11fe60be7502021-05-11T08:24:59ZengNature Publishing GroupNature Communications2041-17232020-02-0111111610.1038/s41467-020-14623-3A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regionsElena Grossi0Ivan Raimondi1Enrique Goñi2Jovanna González3Francesco P. Marchese4Vicente Chapaprieta5José I. Martín-Subero6Shuling Guo7Maite Huarte8Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of NavarraDepartment of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of NavarraDepartment of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of NavarraDepartment of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of NavarraDepartment of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of NavarraDepartament de Fonaments Clinics, Facultat de Medicina, Universitat de BarcelonaDepartament de Fonaments Clinics, Facultat de Medicina, Universitat de BarcelonaDepartment of Antisense Drug Discovery and Clinical Development, Ionis PharmaceuticalsDepartment of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of NavarraSWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional activation of GAS6 and a set of SWI/SNF target genes.https://doi.org/10.1038/s41467-020-14623-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elena Grossi Ivan Raimondi Enrique Goñi Jovanna González Francesco P. Marchese Vicente Chapaprieta José I. Martín-Subero Shuling Guo Maite Huarte
spellingShingle	Elena Grossi Ivan Raimondi Enrique Goñi Jovanna González Francesco P. Marchese Vicente Chapaprieta José I. Martín-Subero Shuling Guo Maite Huarte A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions Nature Communications
author_facet	Elena Grossi Ivan Raimondi Enrique Goñi Jovanna González Francesco P. Marchese Vicente Chapaprieta José I. Martín-Subero Shuling Guo Maite Huarte
author_sort	Elena Grossi
title	A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
title_short	A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
title_full	A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
title_fullStr	A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
title_full_unstemmed	A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
title_sort	lncrna-swi/snf complex crosstalk controls transcriptional activation at specific promoter regions
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-02-01
description	SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional activation of GAS6 and a set of SWI/SNF target genes.
url	https://doi.org/10.1038/s41467-020-14623-3
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A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

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