Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia

Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia

This article presents data demonstrating frequent BAALC hyperexpression, also in combination with WT1 hyperexpression, in children and adults with acute myeloid leukemia (AML). Treatment included allogeneic hematopoietic stem cell transplantation. The analysis of serial measurements of BAALC and WT1...

Full description

Bibliographic Details
Main Authors: NN Mamaev, AI Shakirova, IM Barkhatov, YaV Gudozhnikova, TL Gindina, OV Paina, LS Zubarovskaya, BV Afanas’ev
Format: Article
Language:Russian
Published: Practical Medicine Publishing House 2019-12-01
Series:Kliničeskaâ onkogematologiâ
Subjects:
acute myeloid leukemia
baalc and wt1 genes
synchronous hyperexpression
post-transplantation relapses
baalc–producing progenitor cells
prognosis
Online Access: http://bloodjournal.ru/wp-content/uploads/2019/12/7.pdf
id doaj-31281898624a4af3922299f37fbd85ed
record_format Article
spelling doaj-31281898624a4af3922299f37fbd85ed2020-11-25T02:02:51ZrusPractical Medicine Publishing HouseKliničeskaâ onkogematologiâ1997-69332500-21392019-12-01131758810.21320/2500-2139-2020-13-1-75-8819976933Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid LeukemiaNN Mamaev0AI Shakirova1IM Barkhatov2YaV Gudozhnikova3TL Gindina4OV Paina5LS Zubarovskaya6BV Afanas’ev7 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 This article presents data demonstrating frequent BAALC hyperexpression, also in combination with WT1 hyperexpression, in children and adults with acute myeloid leukemia (AML). Treatment included allogeneic hematopoietic stem cell transplantation. The analysis of serial measurements of BAALC and WT1 expression level in 50 AML patients (37 adults and 13 children) showed that the increased BAALC expression is more common in patients with M1, M2, M4, and M5 FAB variants of AML with equal frequency in adults and children. Furthermore, the increased BAALC expression was rather common in combination with the increased WT1 expression, which predicted poorer prognosis. Since BAALC expression level in AML patients is closely related to AML-producing progenitor cells of leukemia hematopoiesis, a serial study of this phenomenon offers insights into the role of these cells in emergence and development of post-transplantation relapses, which is of both theoretical and practical importance. http://bloodjournal.ru/wp-content/uploads/2019/12/7.pdf acute myeloid leukemiabaalc and wt1 genessynchronous hyperexpressionpost-transplantation relapsesbaalc–producing progenitor cellsprognosis
collection DOAJ
language Russian
format Article
sources DOAJ
author NN Mamaev
AI Shakirova
IM Barkhatov
YaV Gudozhnikova
TL Gindina
OV Paina
LS Zubarovskaya
BV Afanas’ev
spellingShingle NN Mamaev
AI Shakirova
IM Barkhatov
YaV Gudozhnikova
TL Gindina
OV Paina
LS Zubarovskaya
BV Afanas’ev
Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia
Kliničeskaâ onkogematologiâ
acute myeloid leukemia
baalc and wt1 genes
synchronous hyperexpression
post-transplantation relapses
baalc–producing progenitor cells
prognosis
author_facet NN Mamaev
AI Shakirova
IM Barkhatov
YaV Gudozhnikova
TL Gindina
OV Paina
LS Zubarovskaya
BV Afanas’ev
author_sort NN Mamaev
title Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia
title_short Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia
title_full Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia
title_fullStr Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia
title_full_unstemmed Crucial Role of BAALC-Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia
title_sort crucial role of baalc-expressing progenitor cells in emergence and development of post-transplantation relapses in patients with acute myeloid leukemia
publisher Practical Medicine Publishing House
series Kliničeskaâ onkogematologiâ
issn 1997-6933
2500-2139
publishDate 2019-12-01
description This article presents data demonstrating frequent BAALC hyperexpression, also in combination with WT1 hyperexpression, in children and adults with acute myeloid leukemia (AML). Treatment included allogeneic hematopoietic stem cell transplantation. The analysis of serial measurements of BAALC and WT1 expression level in 50 AML patients (37 adults and 13 children) showed that the increased BAALC expression is more common in patients with M1, M2, M4, and M5 FAB variants of AML with equal frequency in adults and children. Furthermore, the increased BAALC expression was rather common in combination with the increased WT1 expression, which predicted poorer prognosis. Since BAALC expression level in AML patients is closely related to AML-producing progenitor cells of leukemia hematopoiesis, a serial study of this phenomenon offers insights into the role of these cells in emergence and development of post-transplantation relapses, which is of both theoretical and practical importance.
topic acute myeloid leukemia
baalc and wt1 genes
synchronous hyperexpression
post-transplantation relapses
baalc–producing progenitor cells
prognosis
url http://bloodjournal.ru/wp-content/uploads/2019/12/7.pdf
work_keys_str_mv AT nnmamaev crucialroleofbaalcexpressingprogenitorcellsinemergenceanddevelopmentofposttransplantationrelapsesinpatientswithacutemyeloidleukemia
AT aishakirova crucialroleofbaalcexpressingprogenitorcellsinemergenceanddevelopmentofposttransplantationrelapsesinpatientswithacutemyeloidleukemia
AT imbarkhatov crucialroleofbaalcexpressingprogenitorcellsinemergenceanddevelopmentofposttransplantationrelapsesinpatientswithacutemyeloidleukemia
AT yavgudozhnikova crucialroleofbaalcexpressingprogenitorcellsinemergenceanddevelopmentofposttransplantationrelapsesinpatientswithacutemyeloidleukemia
AT tlgindina crucialroleofbaalcexpressingprogenitorcellsinemergenceanddevelopmentofposttransplantationrelapsesinpatientswithacutemyeloidleukemia
AT ovpaina crucialroleofbaalcexpressingprogenitorcellsinemergenceanddevelopmentofposttransplantationrelapsesinpatientswithacutemyeloidleukemia
AT lszubarovskaya crucialroleofbaalcexpressingprogenitorcellsinemergenceanddevelopmentofposttransplantationrelapsesinpatientswithacutemyeloidleukemia
AT bvafanasev crucialroleofbaalcexpressingprogenitorcellsinemergenceanddevelopmentofposttransplantationrelapsesinpatientswithacutemyeloidleukemia
_version_ 1724951011944038400

Similar Items