Specific eradication of HIV-1 from infected cultured cells

Specific eradication of HIV-1 from infected cultured cells

<p>Abstract</p> <p>A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused...

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Main Authors: Levin Aviad, Hayouka Zvi, Friedler Assaf, Loyter Abraham
Format: Article
Language:English
Published: BMC 2010-08-01
Series:AIDS Research and Therapy
Online Access:http://www.aidsrestherapy.com/content/7/1/31
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spelling doaj-3127d2962bed4d5b8964fed376d9784c2020-11-25T01:59:16ZengBMCAIDS Research and Therapy1742-64052010-08-01713110.1186/1742-6405-7-31Specific eradication of HIV-1 from infected cultured cellsLevin AviadHayouka ZviFriedler AssafLoyter Abraham<p>Abstract</p> <p>A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.</p> http://www.aidsrestherapy.com/content/7/1/31
collection DOAJ
language English
format Article
sources DOAJ
author Levin Aviad
Hayouka Zvi
Friedler Assaf
Loyter Abraham
spellingShingle Levin Aviad
Hayouka Zvi
Friedler Assaf
Loyter Abraham
Specific eradication of HIV-1 from infected cultured cells
AIDS Research and Therapy
author_facet Levin Aviad
Hayouka Zvi
Friedler Assaf
Loyter Abraham
author_sort Levin Aviad
title Specific eradication of HIV-1 from infected cultured cells
title_short Specific eradication of HIV-1 from infected cultured cells
title_full Specific eradication of HIV-1 from infected cultured cells
title_fullStr Specific eradication of HIV-1 from infected cultured cells
title_full_unstemmed Specific eradication of HIV-1 from infected cultured cells
title_sort specific eradication of hiv-1 from infected cultured cells
publisher BMC
series AIDS Research and Therapy
issn 1742-6405
publishDate 2010-08-01
description <p>Abstract</p> <p>A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.</p>
url http://www.aidsrestherapy.com/content/7/1/31
work_keys_str_mv AT levinaviad specificeradicationofhiv1frominfectedculturedcells
AT hayoukazvi specificeradicationofhiv1frominfectedculturedcells
AT friedlerassaf specificeradicationofhiv1frominfectedculturedcells
AT loyterabraham specificeradicationofhiv1frominfectedculturedcells
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