Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain

The ability to produce novel ideas is central to societal progress and innovation; however, little is known about the biological basis of creativity. Here, we investigate the organization of brain networks that support creativity by combining functional neuroimaging data with gene expression informa...

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Main Authors:	William Orwig, Ibai Diez, Elisenda Bueichekú, Patrizia Vannini, Roger Beaty, Jorge Sepulcre
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Human Neuroscience
Subjects:	creativity fMRI functional connectivity genetics synaptic plasticity
Online Access:	https://www.frontiersin.org/articles/10.3389/fnhum.2021.694274/full

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spelling	doaj-311ee64d9a2e45d7b491c4e91f75e7a72021-07-26T12:04:56ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-07-011510.3389/fnhum.2021.694274694274Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human BrainWilliam Orwig0William Orwig1Ibai Diez2Ibai Diez3Elisenda Bueichekú4Elisenda Bueichekú5Patrizia Vannini6Patrizia Vannini7Roger Beaty8Jorge Sepulcre9Jorge Sepulcre10Department of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United StatesDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United StatesDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United StatesDepartment of Neurology, Brigham and Women’s Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Psychology, The Pennsylvania State University, University Park, PA, United StatesDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United StatesThe ability to produce novel ideas is central to societal progress and innovation; however, little is known about the biological basis of creativity. Here, we investigate the organization of brain networks that support creativity by combining functional neuroimaging data with gene expression information. Given the multifaceted nature of creative thinking, we hypothesized that distributed connectivity would not only be related to individual differences in creative ability, but also delineate the cortical distributions of genes involved in synaptic plasticity. We defined neuroimaging phenotypes using a graph theory approach that detects local and distributed network circuits, then characterized the spatial associations between functional connectivity and cortical gene expression distributions. Our findings reveal strong spatial correlations between connectivity maps and sets of genes devoted to synaptic assembly and signaling. This connectomic-transcriptome approach thus identifies gene expression profiles associated with high creative ability, linking cognitive flexibility to neural plasticity in the human brain.https://www.frontiersin.org/articles/10.3389/fnhum.2021.694274/fullcreativityfMRIfunctional connectivitygeneticssynaptic plasticity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	William Orwig William Orwig Ibai Diez Ibai Diez Elisenda Bueichekú Elisenda Bueichekú Patrizia Vannini Patrizia Vannini Roger Beaty Jorge Sepulcre Jorge Sepulcre
spellingShingle	William Orwig William Orwig Ibai Diez Ibai Diez Elisenda Bueichekú Elisenda Bueichekú Patrizia Vannini Patrizia Vannini Roger Beaty Jorge Sepulcre Jorge Sepulcre Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain Frontiers in Human Neuroscience creativity fMRI functional connectivity genetics synaptic plasticity
author_facet	William Orwig William Orwig Ibai Diez Ibai Diez Elisenda Bueichekú Elisenda Bueichekú Patrizia Vannini Patrizia Vannini Roger Beaty Jorge Sepulcre Jorge Sepulcre
author_sort	William Orwig
title	Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
title_short	Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
title_full	Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
title_fullStr	Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
title_full_unstemmed	Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
title_sort	cortical networks of creative ability trace gene expression profiles of synaptic plasticity in the human brain
publisher	Frontiers Media S.A.
series	Frontiers in Human Neuroscience
issn	1662-5161
publishDate	2021-07-01
description	The ability to produce novel ideas is central to societal progress and innovation; however, little is known about the biological basis of creativity. Here, we investigate the organization of brain networks that support creativity by combining functional neuroimaging data with gene expression information. Given the multifaceted nature of creative thinking, we hypothesized that distributed connectivity would not only be related to individual differences in creative ability, but also delineate the cortical distributions of genes involved in synaptic plasticity. We defined neuroimaging phenotypes using a graph theory approach that detects local and distributed network circuits, then characterized the spatial associations between functional connectivity and cortical gene expression distributions. Our findings reveal strong spatial correlations between connectivity maps and sets of genes devoted to synaptic assembly and signaling. This connectomic-transcriptome approach thus identifies gene expression profiles associated with high creative ability, linking cognitive flexibility to neural plasticity in the human brain.
topic	creativity fMRI functional connectivity genetics synaptic plasticity
url	https://www.frontiersin.org/articles/10.3389/fnhum.2021.694274/full
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Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain

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