A two-stage amplified PZT sensor for monitoring lung and heart sounds in discharged pneumonia patients

• Main Authors: Hongbin Chen, Shuai Yu, Haiyang Liu, Jie Liu, Yongguang Xiao, Dandan Wu, Xiaoyu Pan, Cuihong Zhou, Yifeng Lei, Sheng Liu
• Format: Article
• Language: English
• Published: Nature Publishing Group 2021-07-01
• Series: Microsystems & Nanoengineering
• Online Access: https://doi.org/10.1038/s41378-021-00274-x

Abstract Assessment of lung and heart states is of critical importance for patients with pneumonia. In this study, we present a small-sized and ultrasensitive accelerometer for continuous monitoring of lung and heart sounds to evaluate the lung and heart states of patients. Based on two-stage amplification, which consists of an asymmetric gapped cantilever and a charge amplifier, our accelerometer exhibited an extremely high ratio of sensitivity to noise compared with conventional structures. Our sensor achieves a high sensitivity of 9.2 V/g at frequencies less than 1000 Hz, making it suitable to use to monitor weak physiological signals, including heart and lung sounds. For the first time, lung injury, heart injury, and both lung and heart injuries in discharged pneumonia patients were revealed by our sensor device. Our sound sensor also successfully tracked the recovery course of the discharged pneumonia patients. Over time, the lung and heart states of the patients gradually improved after discharge. Our observations were in good agreement with clinical reports. Compared with conventional medical instruments, our sensor device provides rapid and highly sensitive detection of lung and heart sounds, which greatly helps in the evaluation of lung and heart states of pneumonia patients. This sensor provides a cost-effective alternative approach to the diagnosis and prognosis of pneumonia and has the potential for clinical and home-use health monitoring.