The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke

Despite the beneficial effects of exercise and physical activity, there is little knowledge about the effects of different types of physical activity on neural function. The present study assessed the effects of two types of selected aerobic exercises prior to stroke induction and characterized the...

Full description

Bibliographic Details
Main Authors: Mostafa Teymuri Kheravi, Shila Nayebifar, Seyedeh Motahareh Aletaha, Sara Sarhadi
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2021/5595368
id doaj-311c0c200cf6424a84c494baa2b5a826
record_format Article
spelling doaj-311c0c200cf6424a84c494baa2b5a8262021-04-26T00:03:42ZengHindawi LimitedBioMed Research International2314-61412021-01-01202110.1155/2021/5595368The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with StrokeMostafa Teymuri Kheravi0Shila Nayebifar1Seyedeh Motahareh Aletaha2Sara Sarhadi3Department of Physical EducationDepartment of Sport SciencesDepartment of Physical EducationDepartment of Exercise PhysiologyDespite the beneficial effects of exercise and physical activity, there is little knowledge about the effects of different types of physical activity on neural function. The present study assessed the effects of two types of selected aerobic exercises prior to stroke induction and characterized the expression of TrkB, TNF-α, and MMP2 genes in vivo. Forty male adult Wistar rats were exposed to aerobic exercises following randomization into four groups, including swimming + MCAO (Middle Cerebral Artery Occlusion) (n=10), treadmill training + MCAO (n=10), MCAO (n=10), and control (n=10). The swimming + MCAO group included swimming for 30 minutes each day, while the treadmill training + MCAO group program involved running for 30 minutes each day at an intensity of 15 m/min, for three weeks, five days a week. Neurological deficit was assessed using modified criteria at 24 h after the onset of cerebral ischemia. In the control group, the animals worked freely for three weeks without undergoing ischemia. The MCAO group also operated freely for three weeks after they underwent a stroke. Both training groups underwent ischemia after three weeks of training. TrkB, TNF-α, and MMP2 gene expressions were increased in the MCAO+ swimming training and in the MCAO + running training group compared to the control and MCAO groups, respectively. Preconditioning aerobic exercises significantly increased brain trophic support and reduced brain damage conditions in exercise groups, which support the importance of aerobic exercise in the prevention and treatment of stroke.http://dx.doi.org/10.1155/2021/5595368
collection DOAJ
language English
format Article
sources DOAJ
author Mostafa Teymuri Kheravi
Shila Nayebifar
Seyedeh Motahareh Aletaha
Sara Sarhadi
spellingShingle Mostafa Teymuri Kheravi
Shila Nayebifar
Seyedeh Motahareh Aletaha
Sara Sarhadi
The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke
BioMed Research International
author_facet Mostafa Teymuri Kheravi
Shila Nayebifar
Seyedeh Motahareh Aletaha
Sara Sarhadi
author_sort Mostafa Teymuri Kheravi
title The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke
title_short The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke
title_full The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke
title_fullStr The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke
title_full_unstemmed The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke
title_sort effect of two types of exercise preconditioning on the expression of trkb, tnf-α, and mmp2 genes in rats with stroke
publisher Hindawi Limited
series BioMed Research International
issn 2314-6141
publishDate 2021-01-01
description Despite the beneficial effects of exercise and physical activity, there is little knowledge about the effects of different types of physical activity on neural function. The present study assessed the effects of two types of selected aerobic exercises prior to stroke induction and characterized the expression of TrkB, TNF-α, and MMP2 genes in vivo. Forty male adult Wistar rats were exposed to aerobic exercises following randomization into four groups, including swimming + MCAO (Middle Cerebral Artery Occlusion) (n=10), treadmill training + MCAO (n=10), MCAO (n=10), and control (n=10). The swimming + MCAO group included swimming for 30 minutes each day, while the treadmill training + MCAO group program involved running for 30 minutes each day at an intensity of 15 m/min, for three weeks, five days a week. Neurological deficit was assessed using modified criteria at 24 h after the onset of cerebral ischemia. In the control group, the animals worked freely for three weeks without undergoing ischemia. The MCAO group also operated freely for three weeks after they underwent a stroke. Both training groups underwent ischemia after three weeks of training. TrkB, TNF-α, and MMP2 gene expressions were increased in the MCAO+ swimming training and in the MCAO + running training group compared to the control and MCAO groups, respectively. Preconditioning aerobic exercises significantly increased brain trophic support and reduced brain damage conditions in exercise groups, which support the importance of aerobic exercise in the prevention and treatment of stroke.
url http://dx.doi.org/10.1155/2021/5595368
work_keys_str_mv AT mostafateymurikheravi theeffectoftwotypesofexercisepreconditioningontheexpressionoftrkbtnfaandmmp2genesinratswithstroke
AT shilanayebifar theeffectoftwotypesofexercisepreconditioningontheexpressionoftrkbtnfaandmmp2genesinratswithstroke
AT seyedehmotaharehaletaha theeffectoftwotypesofexercisepreconditioningontheexpressionoftrkbtnfaandmmp2genesinratswithstroke
AT sarasarhadi theeffectoftwotypesofexercisepreconditioningontheexpressionoftrkbtnfaandmmp2genesinratswithstroke
AT mostafateymurikheravi effectoftwotypesofexercisepreconditioningontheexpressionoftrkbtnfaandmmp2genesinratswithstroke
AT shilanayebifar effectoftwotypesofexercisepreconditioningontheexpressionoftrkbtnfaandmmp2genesinratswithstroke
AT seyedehmotaharehaletaha effectoftwotypesofexercisepreconditioningontheexpressionoftrkbtnfaandmmp2genesinratswithstroke
AT sarasarhadi effectoftwotypesofexercisepreconditioningontheexpressionoftrkbtnfaandmmp2genesinratswithstroke
_version_ 1714657645233700864