The Dynamics of Oxidized LDL during Atherogenesis

The Dynamics of Oxidized LDL during Atherogenesis

Accumulating evidence indicates that oxidized low-density lipoprotein (OxLDL) is a useful marker for cardiovascular disease. The uptake of OxLDL by scavenger receptors leads to the accumulation of cholesterol within the foam cells of atherosclerotic lesions. OxLDL has many stimulatory effects on vas...

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Main Authors: Hiroyuki Itabe, Takashi Obama, Rina Kato
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Lipids
Online Access:http://dx.doi.org/10.1155/2011/418313
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spelling doaj-3111a20b651144ac846761336ed71a972020-11-24T23:20:26ZengHindawi LimitedJournal of Lipids2090-30302090-30492011-01-01201110.1155/2011/418313418313The Dynamics of Oxidized LDL during AtherogenesisHiroyuki Itabe0Takashi Obama1Rina Kato2Department of Biological Chemistry, Showa University School of Pharmaceutical Sciences, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Biological Chemistry, Showa University School of Pharmaceutical Sciences, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Biological Chemistry, Showa University School of Pharmaceutical Sciences, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanAccumulating evidence indicates that oxidized low-density lipoprotein (OxLDL) is a useful marker for cardiovascular disease. The uptake of OxLDL by scavenger receptors leads to the accumulation of cholesterol within the foam cells of atherosclerotic lesions. OxLDL has many stimulatory effects on vascular cells, and the presence of OxLDL in circulating blood has been established. According to the classical hypothesis, OxLDL accumulates in the atherosclerotic lesions over a long duration, leading to advanced lesions. However, recent studies on time-course changes of OxLDL in vivo raised a possibility that OxLDL can be transferred between the lesions and the circulation. In this paper, the in vivo dynamics of OxLDL are discussed.http://dx.doi.org/10.1155/2011/418313
collection DOAJ
language English
format Article
sources DOAJ
author Hiroyuki Itabe
Takashi Obama
Rina Kato
spellingShingle Hiroyuki Itabe
Takashi Obama
Rina Kato
The Dynamics of Oxidized LDL during Atherogenesis
Journal of Lipids
author_facet Hiroyuki Itabe
Takashi Obama
Rina Kato
author_sort Hiroyuki Itabe
title The Dynamics of Oxidized LDL during Atherogenesis
title_short The Dynamics of Oxidized LDL during Atherogenesis
title_full The Dynamics of Oxidized LDL during Atherogenesis
title_fullStr The Dynamics of Oxidized LDL during Atherogenesis
title_full_unstemmed The Dynamics of Oxidized LDL during Atherogenesis
title_sort dynamics of oxidized ldl during atherogenesis
publisher Hindawi Limited
series Journal of Lipids
issn 2090-3030
2090-3049
publishDate 2011-01-01
description Accumulating evidence indicates that oxidized low-density lipoprotein (OxLDL) is a useful marker for cardiovascular disease. The uptake of OxLDL by scavenger receptors leads to the accumulation of cholesterol within the foam cells of atherosclerotic lesions. OxLDL has many stimulatory effects on vascular cells, and the presence of OxLDL in circulating blood has been established. According to the classical hypothesis, OxLDL accumulates in the atherosclerotic lesions over a long duration, leading to advanced lesions. However, recent studies on time-course changes of OxLDL in vivo raised a possibility that OxLDL can be transferred between the lesions and the circulation. In this paper, the in vivo dynamics of OxLDL are discussed.
url http://dx.doi.org/10.1155/2011/418313
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