M-Cells Contribute to the Entry of an Oral Vaccine but Are Not Essential for the Subsequent Induction of Protective Immunity against Francisella tularensis.

M-Cells Contribute to the Entry of an Oral Vaccine but Are Not Essential for the Subsequent Induction of Protective Immunity against Francisella tularensis.

M-cells (microfold cells) are thought to be a primary conduit of intestinal antigen trafficking. Using an established neutralizing anti-RANKL (Receptor Activator of NF-κB Ligand) antibody treatment to transiently deplete M-cells in vivo, we sought to determine whether intestinal M-cells were require...

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Bibliographic Details
Main Authors: Aimee L Cunningham, M Neal Guentzel, Jieh-Juen Yu, Chiung-Yu Hung, Thomas G Forsthuber, Christopher S Navara, Hideo Yagita, Ifor R Williams, Karl E Klose, Tonyia D Eaves-Pyles, Bernard P Arulanandam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4839702?pdf=render

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