Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD

Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD

The biological effects of insulin signaling are regulated by the phosphorylation of insulin receptor substrate 1 (IRS1) at serine (Ser) residues. In the brain, phosphorylation of IRS1 at specific Ser sites increases in patients with Alzheimer’s disease (AD) and its animal models. However,...

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Bibliographic Details
Main Authors: Wei Wang, Daisuke Tanokashira, Yusuke Fukui, Megumi Maruyama, Chiemi Kuroiwa, Takashi Saito, Takaomi C. Saido, Akiko Taguchi
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Nutrients
Subjects:
IRS1
serine phosphorylation
hippocampus
diabetes
aging
Alzheimer’s disease
memory decline
Aβ
AMPK
energy depletion
Online Access:https://www.mdpi.com/2072-6643/11/8/1942

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