SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

Abstract The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11)...

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Bibliographic Details
Main Authors: Juri Na, Joseph A. Newman, Chee Kin Then, Junetha Syed, Iolanda Vendrell, Ignacio Torrecilla, Sophie Ellermann, Kristijan Ramadan, Roman Fischer, Anne E. Kiltie
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03437-w

Internet

https://doi.org/10.1038/s41419-021-03437-w

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