The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas.

The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas.

Cannabinoids represent unique compounds for treating tumors, including astrocytomas. Whether CB(1) and CB(2) receptors mediate this therapeutic effect is unclear.We generated astrocytoma subclones that express set levels of CB(1) and CB(2), and found that cannabinoids induce apoptosis only in cells...

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Bibliographic Details
Main Authors: Eiron Cudaback, William Marrs, Thomas Moeller, Nephi Stella
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2806825?pdf=render

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