New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

<p>Abstract</p> <p>Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), hav...

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Main Authors: Stanya Kristopher J, Kao Hung-Ying
Format: Article
Language:English
Published: BMC 2009-04-01
Series:Cell Division
Online Access:http://www.celldiv.com/content/4/1/7
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spelling doaj-30f9cf0141384c87a10a27a4e45961582020-11-24T22:04:14ZengBMCCell Division1747-10282009-04-0141710.1186/1747-1028-4-7New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoRStanya Kristopher JKao Hung-Ying<p>Abstract</p> <p>Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.</p> http://www.celldiv.com/content/4/1/7
collection DOAJ
language English
format Article
sources DOAJ
author Stanya Kristopher J
Kao Hung-Ying
spellingShingle Stanya Kristopher J
Kao Hung-Ying
New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
Cell Division
author_facet Stanya Kristopher J
Kao Hung-Ying
author_sort Stanya Kristopher J
title New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
title_short New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
title_full New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
title_fullStr New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
title_full_unstemmed New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
title_sort new insights into the functions and regulation of the transcriptional corepressors smrt and n-cor
publisher BMC
series Cell Division
issn 1747-1028
publishDate 2009-04-01
description <p>Abstract</p> <p>Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.</p>
url http://www.celldiv.com/content/4/1/7
work_keys_str_mv AT stanyakristopherj newinsightsintothefunctionsandregulationofthetranscriptionalcorepressorssmrtandncor
AT kaohungying newinsightsintothefunctionsandregulationofthetranscriptionalcorepressorssmrtandncor
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