<i>SLC19A3</i> Loss-of-Function Variant in Yorkshire Terriers with Leigh-Like Subacute Necrotizing Encephalopathy

<i>SLC19A3</i> Loss-of-Function Variant in Yorkshire Terriers with Leigh-Like Subacute Necrotizing Encephalopathy

Sporadic occurrence of juvenile-onset necrotizing encephalopathy (SNE) has been previously reported in Yorkshire terriers. However, so far, no causative genetic variant has been found for this breed-specific form of suspected mitochondrial encephalomyopathy. Affected dogs showed gait abnormalities,...

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Bibliographic Details
Main Authors: Michaela Drögemüller, Anna Letko, Kaspar Matiasek, Vidhya Jagannathan, Daniele Corlazzoli, Marco Rosati, Konrad Jurina, Susanne Medl, Thomas Gödde, Stefan Rupp, Andrea Fischer, Alejandro Luján Feliu-Pascual, Cord Drögemüller
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Genes
Subjects:
<i>Canis familiaris</i>
whole-genome sequencing
rare disease
precision medicine
neurometabolic disorder
Online Access:https://www.mdpi.com/2073-4425/11/10/1215

Internet

https://www.mdpi.com/2073-4425/11/10/1215

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