Flagellar cAMP signaling controls trypanosome progression through host tissues
Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lu...
Main Authors: | Sebastian Shaw, Stephanie F. DeMarco, Ruth Rehmann, Tanja Wenzler, Francesca Florini, Isabel Roditi, Kent L. Hill |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-08696-y |
Similar Items
-
An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition.
by: Shubha Bevkal, et al.
Published: (2021-01-01) -
Studies on the flagellar attachment of African trypanosomes
by: Hendry, Kay Alexandra Kidd
Published: (1987) -
Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes.
by: Katherine S Ralston, et al.
Published: (2006-09-01) -
Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication? [version 1; referees: 2 approved]
by: Simon Imhof, et al.
Published: (2016-04-01) -
The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins
by: Aabha I. Sharma, et al.
Published: (2017-08-01)