Flagellar cAMP signaling controls trypanosome progression through host tissues

Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lu...

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Main Authors:	Sebastian Shaw, Stephanie F. DeMarco, Ruth Rehmann, Tanja Wenzler, Francesca Florini, Isabel Roditi, Kent L. Hill
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08696-y

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spelling	doaj-30f4254f1f9248b0a285b1c1494715d52021-05-11T12:00:57ZengNature Publishing GroupNature Communications2041-17232019-02-0110111310.1038/s41467-019-08696-yFlagellar cAMP signaling controls trypanosome progression through host tissuesSebastian Shaw0Stephanie F. DeMarco1Ruth Rehmann2Tanja Wenzler3Francesca Florini4Isabel Roditi5Kent L. Hill6Institute of Cell Biology, University of Bern, Baltzerstrasse 4Molecular Biology Institute, University of CaliforniaInstitute of Cell Biology, University of Bern, Baltzerstrasse 4Institute of Cell Biology, University of Bern, Baltzerstrasse 4Institute of Cell Biology, University of Bern, Baltzerstrasse 4Institute of Cell Biology, University of Bern, Baltzerstrasse 4Molecular Biology Institute, University of CaliforniaTrypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lumen.https://doi.org/10.1038/s41467-019-08696-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sebastian Shaw Stephanie F. DeMarco Ruth Rehmann Tanja Wenzler Francesca Florini Isabel Roditi Kent L. Hill
spellingShingle	Sebastian Shaw Stephanie F. DeMarco Ruth Rehmann Tanja Wenzler Francesca Florini Isabel Roditi Kent L. Hill Flagellar cAMP signaling controls trypanosome progression through host tissues Nature Communications
author_facet	Sebastian Shaw Stephanie F. DeMarco Ruth Rehmann Tanja Wenzler Francesca Florini Isabel Roditi Kent L. Hill
author_sort	Sebastian Shaw
title	Flagellar cAMP signaling controls trypanosome progression through host tissues
title_short	Flagellar cAMP signaling controls trypanosome progression through host tissues
title_full	Flagellar cAMP signaling controls trypanosome progression through host tissues
title_fullStr	Flagellar cAMP signaling controls trypanosome progression through host tissues
title_full_unstemmed	Flagellar cAMP signaling controls trypanosome progression through host tissues
title_sort	flagellar camp signaling controls trypanosome progression through host tissues
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lumen.
url	https://doi.org/10.1038/s41467-019-08696-y
work_keys_str_mv	AT sebastianshaw flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT stephaniefdemarco flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT ruthrehmann flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT tanjawenzler flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT francescaflorini flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT isabelroditi flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT kentlhill flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues
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Flagellar cAMP signaling controls trypanosome progression through host tissues

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