An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease
Abstract Introduction Genome-wide association studies (GWAS) have successfully identified multiple independent genetic loci that harbour variants associated with Alzheimer’s disease, but the exact causal genes and biological pathways are largely unknown. Methods To prioritise likely causal genes ass...
Main Authors: | Zachary F. Gerring, Michelle K. Lupton, Daniel Edey, Eric R. Gamazon, Eske M. Derks |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-04-01
|
Series: | Alzheimer’s Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13195-020-00611-8 |
Similar Items
-
A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
by: Yanfa Sun, et al.
Published: (2021-09-01) -
Genetic Overlap Between Alzheimer’s Disease and Depression Mapped Onto the Brain
by: Jennifer Monereo-Sánchez, et al.
Published: (2021-07-01) -
Multiple susceptibility loci at chromosome 11q23.3 are associated with plasma triglyceride in East Asians[S]
by: Bayasgalan Gombojav, et al.
Published: (2016-02-01) -
Similar Genetic Architecture of Alzheimer’s Disease and Differential APOE Effect Between Sexes
by: Hao Wang, et al.
Published: (2021-05-01) -
Genetic disease risks can be misestimated across global populations
by: Michelle S. Kim, et al.
Published: (2018-11-01)