Cytotoxic flavonoids from Erythrina caffra Thunb

Erythrina caffra is an important medicinal plant native to South Africa. Its stem bark was investigated for the flavonoid constituents and biological activity. Some isolated flavonoids, 3, 5, 6, 8, 9, 10, 11, 12, 13, 15 and 16 were found to be active against the human cervix carcinoma KB-3-1 cell...

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Main Authors:	Z. Y. Desta, N. Sewald, R. R.T. Majinda
Format:	Article
Language:	English
Published:	Chemical Society of Ethiopia 2017-01-01
Series:	Bulletin of the Chemical Society of Ethiopia
Subjects:	Erythrina caffra Cytotoxicity Antibacterial Flavonoids Fabaceae
Online Access:	https://www.ajol.info/index.php/bcse/article/view/149961

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spelling	doaj-30f1b4015bcc4d10807a24b379914ace2020-11-24T22:21:25ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2017-01-01303427435http://dx.doi.org/10.4314/bcse.v30i3.11Cytotoxic flavonoids from Erythrina caffra ThunbZ. Y. DestaN. Sewald R. R.T. MajindaErythrina caffra is an important medicinal plant native to South Africa. Its stem bark was investigated for the flavonoid constituents and biological activity. Some isolated flavonoids, 3, 5, 6, 8, 9, 10, 11, 12, 13, 15 and 16 were found to be active against the human cervix carcinoma KB-3-1 cells with IC50 values in the micromolar range. Compounds 8, 9, 11, 13 and 15 also showed weak to moderate antibacterial activity against some organisms using the disc diffusion assay at loadings of 62.5 μg/disc (8, 11) and 125 μg/disc (9, 13, 15).https://www.ajol.info/index.php/bcse/article/view/149961Erythrina caffraCytotoxicityAntibacterialFlavonoidsFabaceae
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Z. Y. Desta N. Sewald R. R.T. Majinda
spellingShingle	Z. Y. Desta N. Sewald R. R.T. Majinda Cytotoxic flavonoids from Erythrina caffra Thunb Bulletin of the Chemical Society of Ethiopia Erythrina caffra Cytotoxicity Antibacterial Flavonoids Fabaceae
author_facet	Z. Y. Desta N. Sewald R. R.T. Majinda
author_sort	Z. Y. Desta
title	Cytotoxic flavonoids from Erythrina caffra Thunb
title_short	Cytotoxic flavonoids from Erythrina caffra Thunb
title_full	Cytotoxic flavonoids from Erythrina caffra Thunb
title_fullStr	Cytotoxic flavonoids from Erythrina caffra Thunb
title_full_unstemmed	Cytotoxic flavonoids from Erythrina caffra Thunb
title_sort	cytotoxic flavonoids from erythrina caffra thunb
publisher	Chemical Society of Ethiopia
series	Bulletin of the Chemical Society of Ethiopia
issn	1011-3924 1726-801X
publishDate	2017-01-01
description	Erythrina caffra is an important medicinal plant native to South Africa. Its stem bark was investigated for the flavonoid constituents and biological activity. Some isolated flavonoids, 3, 5, 6, 8, 9, 10, 11, 12, 13, 15 and 16 were found to be active against the human cervix carcinoma KB-3-1 cells with IC50 values in the micromolar range. Compounds 8, 9, 11, 13 and 15 also showed weak to moderate antibacterial activity against some organisms using the disc diffusion assay at loadings of 62.5 μg/disc (8, 11) and 125 μg/disc (9, 13, 15).
topic	Erythrina caffra Cytotoxicity Antibacterial Flavonoids Fabaceae
url	https://www.ajol.info/index.php/bcse/article/view/149961
work_keys_str_mv	AT zydesta cytotoxicflavonoidsfromerythrinacaffrathunb AT nsewald cytotoxicflavonoidsfromerythrinacaffrathunb AT rrtmajinda cytotoxicflavonoidsfromerythrinacaffrathunb
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Cytotoxic flavonoids from Erythrina caffra Thunb

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