Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer
Background: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic options. Epidermal growth factor receptor (EGFR) has been shown to be over-expressed in TNBC and represents a rational treatment target. Methods: We examined single agent and combinati...
Main Authors: | Alexandra Canonici, Alacoque L. Browne, Mohamed F. K. Ibrahim, Kevin P. Fanning, Sandra Roche, Neil T. Conlon, Fiona O’Neill, Justine Meiller, Mattia Cremona, Clare Morgan, Bryan T. Hennessy, Alex J. Eustace, Flavio Solca, Norma O’Donovan, John Crown |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2020-01-01
|
Series: | Therapeutic Advances in Medical Oncology |
Online Access: | https://doi.org/10.1177/1758835919897546 |
Similar Items
-
Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines
by: Clynes Martin, et al.
Published: (2008-09-01) -
Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models.
by: Tapesh Santra, et al.
Published: (2017-01-01) -
Alterations in integrin expression modulates invasion of pancreatic cancer cells
by: Crown John, et al.
Published: (2009-10-01) -
c-Src Increases the Sensitivity to TKIs in the EGFR-Mutant Lung Adenocarcinoma
by: Weili Min, et al.
Published: (2021-07-01) -
mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells
by: Barbara Colella, et al.
Published: (2020-08-01)