Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy

Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy

BACKGROUND The anti-inflammatory and cardioprotective properties of curcumin (Cur), a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa, are increasingly considered to have beneficial effects on the progression of Chagas heart disease, caused by the protozoan parasite Trypa...

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Bibliographic Details
Main Authors: Matías Hernández, Susana Wicz, Miguel H Santamaría, Ricardo S Corral
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2018-07-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Chagas disease
cardiomyopathy
curcumin
endothelin-1
vasculitis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000900302&lng=en&tlng=en

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