PHLD Class Proteins: A Family of New Players in the p53 Network
The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago, this clas...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/10/3543 |
| id |
doaj-30da80fb4adc46efa0d79d9252c5c7ec |
|---|---|
| record_format |
Article |
| spelling |
doaj-30da80fb4adc46efa0d79d9252c5c7ec2020-11-25T02:15:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01213543354310.3390/ijms21103543PHLD Class Proteins: A Family of New Players in the p53 NetworkTaylor T. Fuselier0Hua Lu1Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USATulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USAThe Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago, this class of proteins remains understudied with PHLDA family members receiving most of the research attention. Recent studies have also begun to reveal the functions of the PHLDB family proteins in regulation of p53 and AKT signaling pathways important for cancer and metabolism. This review will discuss current research and offer some prospects on the possible roles of both families in cancer and metabolism.https://www.mdpi.com/1422-0067/21/10/3543PHLDAPHLDBp53AKT signalingcancermetabolism |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Taylor T. Fuselier Hua Lu |
| spellingShingle |
Taylor T. Fuselier Hua Lu PHLD Class Proteins: A Family of New Players in the p53 Network International Journal of Molecular Sciences PHLDA PHLDB p53 AKT signaling cancer metabolism |
| author_facet |
Taylor T. Fuselier Hua Lu |
| author_sort |
Taylor T. Fuselier |
| title |
PHLD Class Proteins: A Family of New Players in the p53 Network |
| title_short |
PHLD Class Proteins: A Family of New Players in the p53 Network |
| title_full |
PHLD Class Proteins: A Family of New Players in the p53 Network |
| title_fullStr |
PHLD Class Proteins: A Family of New Players in the p53 Network |
| title_full_unstemmed |
PHLD Class Proteins: A Family of New Players in the p53 Network |
| title_sort |
phld class proteins: a family of new players in the p53 network |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1661-6596 1422-0067 |
| publishDate |
2020-05-01 |
| description |
The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago, this class of proteins remains understudied with PHLDA family members receiving most of the research attention. Recent studies have also begun to reveal the functions of the PHLDB family proteins in regulation of p53 and AKT signaling pathways important for cancer and metabolism. This review will discuss current research and offer some prospects on the possible roles of both families in cancer and metabolism. |
| topic |
PHLDA PHLDB p53 AKT signaling cancer metabolism |
| url |
https://www.mdpi.com/1422-0067/21/10/3543 |
| work_keys_str_mv |
AT taylortfuselier phldclassproteinsafamilyofnewplayersinthep53network AT hualu phldclassproteinsafamilyofnewplayersinthep53network |
| _version_ |
1724896035052978176 |