Development of Validated Methods and Quantification of Curcuminoids and Curcumin Metabolites and Their Pharmacokinetic Study of Oral Administration of Complete Natural Turmeric Formulation (Cureit™) in Human Plasma via UPLC/ESI-Q-TOF-MS Spectrometry

Development of Validated Methods and Quantification of Curcuminoids and Curcumin Metabolites and Their Pharmacokinetic Study of Oral Administration of Complete Natural Turmeric Formulation (Cureit™) in Human Plasma via UPLC/ESI-Q-TOF-MS Spectrometry

Specific and sensitive ultra-high performance liquid chromatography-quadrupole time of flight-mass spectroscopy (UPLC-QTOF-MS) methods have been developed for the determination of curcuminoids and curcumin metabolites in human blood plasma. The UPLC-QTOF-MS method used a binary solvent delivery syst...

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Bibliographic Details
Main Authors: Shintu Jude, Augustine Amalraj, Ajaikumar B. Kunnumakkara, Chandradhara Divya, Bernd-Michael Löffler, Sreeraj Gopi
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
curcuminoids
curcumin metabolites
UPLC/ESI-Q-TOF-MS spectrometry
pharmacokinetic
bioavailable curcumin (Cureit™)
Online Access:http://www.mdpi.com/1420-3049/23/10/2415

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