Kitamura Electrophilic Fluorination Using HF as a Source of Fluorine

Kitamura Electrophilic Fluorination Using HF as a Source of Fluorine

This review article focused on the innovative procedure for electrophilic fluorination using HF and in situ generation of the required electrophilic species derived from hypervalent iodine compounds. The areas of synthetic application of this approach include fluorination of 1,3-dicarbonyl compounds...

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Bibliographic Details
Main Authors: Jianlin Han, Greg Butler, Hiroki Moriwaki, Hiroyuki Konno, Vadim A. Soloshonok, Tsugio Kitamura
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
electrophilic fluorination
hydrogen fluoride
hypervalent iodine
fluorination reagents
bioactive compounds
Online Access:https://www.mdpi.com/1420-3049/25/9/2116
Description
Summary:This review article focused on the innovative procedure for electrophilic fluorination using HF and in situ generation of the required electrophilic species derived from hypervalent iodine compounds. The areas of synthetic application of this approach include fluorination of 1,3-dicarbonyl compounds, aryl-alkyl ketones, styrene derivatives, α,β-unsaturated ketones and alcohols, homoallyl amine and homoallyl alcohol derivatives, 3-butenoic acids and alkynes.
ISSN:1420-3049

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