Chronic retinal detachment and neovascular glaucoma after intravitreal stem cell injection for Usher Syndrome

• Main Authors: Kay T. Khine, Thomas A. Albini, Richard K. Lee
• Format: Article
• Language: English
• Published: Elsevier 2020-06-01
• Series: American Journal of Ophthalmology Case Reports
• Subjects: Stem cells; Autologous stem cell transplantation; Retinitis pigmentosa; Neovascular glaucoma; US stem cell clinics; Intravitreal injection of stem cells
• Online Access: http://www.sciencedirect.com/science/article/pii/S2451993618302433

A 42-year-old Hispanic female underwent intravitreal autologous adipose-tissue derived stem cell injection to her left eye in the Dominican Republic for treatment of retinitis pigmentosa associated with Usher Syndrome. Prior to intravitreal injection, the patient's best-corrected-visual-acuity (BCVA) was 1/200. The patient experienced decreased vision gradually over a 3-month period. The patient presented with no light perception (NLP) vision with a total funnel retinal detachment, as well as hyphema, iris neovascularization, and nearly 360 posterior synechiae of the iris to the lens capsule. The patient suffered from ocular pain with an intraocular pressure (IOP) of 37 mm Hg. Transcleral cyclophotocoagulation was performed. The IOP was 6 mm Hg six weeks after treatment and the patient was pain free.