Rectal cancer sub-clones respond differentially to neoadjuvant therapy

Rectal cancer sub-clones respond differentially to neoadjuvant therapy

Treatment of locally advanced rectal cancer includes chemotherapy, radiation, and surgery but patient responses to neoadjuvant treatment are variable. We have shown that rectal tumors are comprised of multiple genetically distinct sub-clones. Unique sub-clones within tumors may harbor mutations whic...

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Bibliographic Details
Main Authors:	Lynn M Frydrych, Peter Ulintz, Armand Bankhead, Christopher Sifuentes, Joel Greenson, Lillias Maguire, Regina Irwin, Eric R. Fearon, Karin M Hardiman
Format:	Article
Language:	English
Published:	Elsevier 2019-10-01
Series:	Neoplasia: An International Journal for Oncology Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558619302441

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